Molecules (Feb 1998)
A Short and Efficient Synthesis of (R)-Phoracantholide I
Abstract
A short and efficient chemoenzymatic synthesis of the title compound has been developed. The salient features of the synthesis were i) preparation of the required chiron via a porcine pancreatic lipase (PPL) catalyzed esterification of a É-functionalized 2-alkanol and ii) use of easily accessible and inexpensive materials/ reagents.
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