Preparation and evaluation of PEGylated phospholipid membrane coated layered double hydroxide nanoparticles

Abstract

The aim of the present study was to develop layered double hydroxide (LDH) nanoparticles coated with PEGylated phospholipid membrane. By comparing the size distribution and zeta potential, the weight ratio of LDH to lipid materials which constitute the outside membrane was identified as 2:1. Transmission electron microscopy photographs confirmed the core-shell structure of PEGylated phospholipid membrane coated LDH (PEG-PLDH) nanoparticles, and cell cytotoxicity assay showed their good cell viability on Hela and BALB/C-3T3 cells over the concentration range from 0.5 to 50 μg/mL.

Keywords

• Preparation
• In vitro evaluation
• Layered double hydroxides
• Phospholipid membrane
• Size distribution
• Zeta potential