Synthesis and Fungicidal Activity of Novel 2,3-Disubstituted-1,3-benzoxazines

Abstract

A series of new 2,3-disubstituted-3,4-dihydro-2<em>H</em>-1,3-benzoxazines were prepared in moderate to excellent yields by aza-acetalizations of aromatic aldehydes with 2-(<em>N</em>-substituted aminomethyl)phenols in the presence of TMSCl. Their structures were confirmed by IR, ¹H-NMR, ¹³C-NMR, MS and elemental analysis. The fungicidal activities of the target compounds were preliminarily evaluated, and some compounds exhibited good activity against <em>Rhizoctonia solani</em>.

Keywords

• 2,3-disubstituted-1,3-benzoxazine
• synthesis
• chlorotrimethylsilane
• fungicidal activity