A Simple, Proficient and Green Approach for the Synthesis of 1,8-Dioxo-octahydroxanthenes Catalyzed by Cerium(IV) Ammonium Nitrate in Aqueous Media

Abstract

Various biologically important 1,8-dioxo-“octahydroxanthene derivatives” have been efficiently synthesized in excellent yields using catalytic amounts of cerium(IV) ammonium nitrate (CAN) in water. This inexpensive, non-toxic, and readily available catalytic system (10 mol%) in water efficiently catalyzes the condensation reaction of various aromatic aldehydes and dimedone to yield the products in excellent yield. Besides, ambient conditions, excellent product yields and water as a universal solvent display both economic and environmental advantages.

Keywords

• eco-friendly
• dimedone
• green chemistry