Nature Communications (Jun 2021)

Structure and transport mechanism of P5B-ATPases

  • Ping Li,
  • Kaituo Wang,
  • Nina Salustros,
  • Christina Grønberg,
  • Pontus Gourdon

DOI
https://doi.org/10.1038/s41467-021-24148-y
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 8

Abstract

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In human cells, P5B‐ATPases execute export of spermine from lysosomes to the cytosol, but the mechanisms of spermine recognition, uptake and transport remain elusive. Here the authors present cryo‐EM structures of a yeast homolog of human ATP13A2‐5, Ypk9, which depict three separate transport cycle intermediates, including spermine‐bound conformations