GPR55 activation improves anxiety- and depression-like behaviors of mice during methamphetamine withdrawal
Jinlong Zhang,
Jie Yan,
Shuyue Li,
Qianqian Chen,
Jiang Lin,
Yilin Peng,
Yuhang Liu,
Binbin Wang,
Xinrong Wei,
Chen Sun,
Shuliang Niu
Affiliations
Jinlong Zhang
Department of Forensic Science, School of Basic Medical Science, Xinjiang Medical University, Urumqi, 830011, China; Department of Forensic Science, School of Basic Medical Science, Central South University, Changsha, 410000, China
Jie Yan
Department of Forensic Science, School of Basic Medical Science, Xinjiang Medical University, Urumqi, 830011, China; Department of Forensic Science, School of Basic Medical Science, Central South University, Changsha, 410000, China
Shuyue Li
Department of Forensic Science, School of Basic Medical Science, Xinjiang Medical University, Urumqi, 830011, China
Qianqian Chen
Department of Forensic Science, School of Basic Medical Science, Central South University, Changsha, 410000, China
Jiang Lin
Department of Forensic Science, School of Basic Medical Science, Central South University, Changsha, 410000, China
Yilin Peng
Department of Forensic Science, School of Basic Medical Science, Central South University, Changsha, 410000, China
Yuhang Liu
Department of Forensic Science, School of Basic Medical Science, Central South University, Changsha, 410000, China
Binbin Wang
Department of Forensic Science, School of Basic Medical Science, Central South University, Changsha, 410000, China
Xinrong Wei
Department of Forensic Science, School of Basic Medical Science, Xinjiang Medical University, Urumqi, 830011, China
Chen Sun
School of Public Health, Xinjiang Medical University, Urumqi, 830011, China
Shuliang Niu
Department of Forensic Science, School of Basic Medical Science, Xinjiang Medical University, Urumqi, 830011, China; Department of Human Anatomy, School of Basic Medical Sciences, Xinjiang Medical University, Urumqi, 830011, China; Corresponding author. Department of Human Anatomy, School of Basic Medical Sciences, Xinjiang Medical University, Urumqi, 830011, China.
Methamphetamine is a potent and highly addictive neurotoxic psychostimulant that triggers a spectrum of adverse emotional responses during withdrawal. G-protein coupled receptor 55 (GPR55), a novel endocannabinoid receptor, is closely associated with mood regulation. Herein, we developed a murine model of methamphetamine-induced anxiety- and depressive-like behavior during abstinence which showed a decreased GPR55 expression in the hippocampus. Activation of GPR55 mitigated these behavioral symptoms, concomitantly ameliorating impairments in hippocampal neurogenesis and reducing neuroinflammation. These findings underscore the pivotal role of GPR55 in mediating the neuropsychological consequences of methamphetamine withdrawal, potentially via mechanisms involving the modulation of hippocampal neurogenesis and inflammation.
