RBM3 promotes neurogenesis in a niche-dependent manner via IMP2-IGF2 signaling pathway after hypoxic-ischemic brain injury

Xinzhou Zhu; Jingyi Yan; Catherine Bregere; Andrea Zelmer; Tessa Goerne; Josef P. Kapfhammer; Raphael Guzman; Sven Wellmann

doi:10.1038/s41467-019-11870-x

Nature Communications (Sep 2019)

RBM3 promotes neurogenesis in a niche-dependent manner via IMP2-IGF2 signaling pathway after hypoxic-ischemic brain injury

Xinzhou Zhu,
Jingyi Yan,
Catherine Bregere,
Andrea Zelmer,
Tessa Goerne,
Josef P. Kapfhammer,
Raphael Guzman,
Sven Wellmann

Affiliations

Xinzhou Zhu: University Children’s Hospital Basel (UKBB), University of Basel
Jingyi Yan: University Children’s Hospital Basel (UKBB), University of Basel
Catherine Bregere: Department of Biomedicine, University of Basel
Andrea Zelmer: University Children’s Hospital Basel (UKBB), University of Basel
Tessa Goerne: University Children’s Hospital Basel (UKBB), University of Basel
Josef P. Kapfhammer: Department of Biomedicine, University of Basel
Raphael Guzman: Department of Biomedicine, University of Basel
Sven Wellmann: University Children’s Hospital Basel (UKBB), University of Basel

DOI: https://doi.org/10.1038/s41467-019-11870-x
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 14

Abstract

Read online

Therapeutic hypothermia is a potent tool in the treatment of neonatal hypoxic-ischemic (HI) injury, yet the underlying mechanisms remain unclear. Here, authors demonstrate how the RNA-binding motif protein RBM3, which is induced by mild cooling while global translation rate is slowed down, contributes substantially to neuroregeneration after adult HI injury, specifically in the subventricular zone and subgranular zone.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal