Association between vitamin D receptor gene (BsmI-rs1544410 and FokI-rs2228570) polymorphisms and type 1 diabetes mellitus in Egyptian children

Abstract

Introduction Type 1 diabetes mellitus (T1DM) is an autoimmune disorder triggered by both environmental and genetic risk factors. Although some studies have reported that single-nucleotide polymorphisms of vitamin D receptor (VDR) gene play a role in T1DM susceptibility, their associations are inconclusive and remain controversial in different ethnic groups. This case–control study aimed to evaluate the association between VDR (BsmI-rs1544410 and FokI-rs2228570) single-nucleotide polymorphisms and T1DM in Egyptian children. A total of 100 participants, 50 children with T1DM (cases) and 50 nondiabetic, age-matched and sex-matched patients (controls), were enrolled in the study in which BsmI-rs1544410 and FokI-rs2228570 variants were genotyped using TaqMan real-time PCR technology. Results VDR gene (BsmI-rs1544410 and FokI-rs2228570) variants are not associated with T1DM in Egyptian children. Conclusions VDR (BsmI-rs1544410 and FokI-rs2228570) variants did not differ significantly between T1DM cases and nondiabetic controls among Egyptian children.

Keywords

• bsmi-rs1544410 and foki-rs2228570
• type 1 diabetes mellitus
• vitamin d receptor gene