A case of psoriasiform graft-versus-host disease

Abstract

A rare case of psoriasiform graft-versus-host disease is reported. The patient suffered from acute B-cell leukemia for more than 1 year. Nine months after allogenic hematopoietic stem cell transplantation, the patient developed red papules and plaques, with Auspitz sign positive and silver-white scales on the head, face, limb and trunk. The histopathology showed both psoriatic and interfacial dermatitis. Immunohistochemical staining demonstrated infiltration of CD4+ and CD8+ T cells. Diagnosis was psoriasiform graft-versus-host disease. Lesions were improved by topical 0.1% tacrolimus ointment.

Keywords

• hematopoietic stem cell transplantation
• graft-versus-host disease
• psoriasform
• leukemia