eLife (Dec 2019)

Fly model sheds light on brain disease

Martin H Berryer,
Sara G Kosmaczewski,
Lindy E Barrett

Affiliations

Martin H Berryer: Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, United States; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, United States
Sara G Kosmaczewski: Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, United States; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, United States
Lindy E Barrett: ORCiD; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, United States; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, United States

DOI: https://doi.org/10.7554/eLife.53233
Journal volume & issue: Vol. 8

Abstract

Experiments on flies suggest that a gain-of-function mechanism in a protein called CSPɑ contributes to the progressive brain disease CLN4.

Published in eLife

ISSN: 2050-084X (Online)
Publisher: eLife Sciences Publications Ltd
Country of publisher: United Kingdom
LCC subjects: Medicine; Science: Biology (General)
Website: https://elifesciences.org

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