Nature Communications (Sep 2022)

Evolutionary origin of vertebrate OCT4/POU5 functions in supporting pluripotency

  • Woranop Sukparangsi,
  • Elena Morganti,
  • Molly Lowndes,
  • Hélène Mayeur,
  • Melanie Weisser,
  • Fella Hammachi,
  • Hanna Peradziryi,
  • Fabian Roske,
  • Jurriaan Hölzenspies,
  • Alessandra Livigni,
  • Benoit Gilbert Godard,
  • Fumiaki Sugahara,
  • Shigeru Kuratani,
  • Guillermo Montoya,
  • Stephen R. Frankenberg,
  • Sylvie Mazan,
  • Joshua M. Brickman

DOI
https://doi.org/10.1038/s41467-022-32481-z
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 21

Abstract

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By constructing an evolutionary trajectory of the cyclostome-gnathostome Pou5 gene family and comparing the structural and phenotypic protein variations, the authors uncover the origin of functional characteristics for the pluripotency factor Oct4.