A CRISPR screen identifies genes controlling Etv2 threshold expression in murine hemangiogenic fate commitment

Haiyong Zhao; Kyunghee Choi

doi:10.1038/s41467-017-00667-5

Nature Communications (Sep 2017)

A CRISPR screen identifies genes controlling Etv2 threshold expression in murine hemangiogenic fate commitment

Haiyong Zhao,
Kyunghee Choi

Affiliations

Haiyong Zhao: Department of Pathology and Immunology, Washington University School of Medicine
Kyunghee Choi: Department of Pathology and Immunology, Washington University School of Medicine

DOI: https://doi.org/10.1038/s41467-017-00667-5
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 12

Abstract

Read online

How haematopoietic and endothelial cell lineages are specified is unclear. Here, the authors identify the forkhead transcription factor Foxh1 as regulating FLK1+ mesoderm formation in mouse embryonic stem cells, which in turn specifies hemangiogenic fate via Etv2.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal