Tracking matricellular protein SPARC in extracellular vesicles as a non-destructive method to evaluate lipid-based antifibrotic treatments

Cristina Zivko; Kathrin Fuhrmann; Gregor Fuhrmann; Paola Luciani

doi:10.1038/s42003-022-04123-z

Communications Biology (Oct 2022)

Tracking matricellular protein SPARC in extracellular vesicles as a non-destructive method to evaluate lipid-based antifibrotic treatments

Cristina Zivko,
Kathrin Fuhrmann,
Gregor Fuhrmann,
Paola Luciani

Affiliations

Cristina Zivko: Institute of Pharmacy, Friedrich Schiller University of Jena
Kathrin Fuhrmann: Helmholtz Institute for Pharmaceutical Research Saarland, Department of Pharmacy, Saarland University
Gregor Fuhrmann: Helmholtz Institute for Pharmaceutical Research Saarland, Department of Pharmacy, Saarland University
Paola Luciani: Institute of Pharmacy, Friedrich Schiller University of Jena

DOI: https://doi.org/10.1038/s42003-022-04123-z
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 13

Abstract

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A method is developed to isolate and characterize extracellular vesicles (EVs) from human hepatic stellate cells and proteomics reveals that the matricellular protein SPARC may be used as an EV marker after lipid-based antifibrotic treatment.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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