Discovery of indole-modified aptamers for highly specific recognition of protein glycoforms

Alex M. Yoshikawa; Alexandra Rangel; Trevor Feagin; Elizabeth M. Chun; Leighton Wan; Anping Li; Leonhard Moekl; Diana Wu; Michael Eisenstein; Sharon Pitteri; H. Tom Soh

doi:10.1038/s41467-021-26933-1

Nature Communications (Dec 2021)

Discovery of indole-modified aptamers for highly specific recognition of protein glycoforms

Alex M. Yoshikawa,
Alexandra Rangel,
Trevor Feagin,
Elizabeth M. Chun,
Leighton Wan,
Anping Li,
Leonhard Moekl,
Diana Wu,
Michael Eisenstein,
Sharon Pitteri,
H. Tom Soh

Affiliations

Alex M. Yoshikawa: Department of Chemical Engineering, Stanford University
Alexandra Rangel: Department of Radiology, Stanford University
Trevor Feagin: Department of Radiology, Stanford University
Elizabeth M. Chun: Department of Radiology, Stanford University
Leighton Wan: Department of Bioengineering, Stanford University
Anping Li: Department of Radiology, Stanford University
Leonhard Moekl: Department of Chemistry, Stanford University
Diana Wu: Department of Bioengineering, Stanford University
Michael Eisenstein: Department of Radiology, Stanford University
Sharon Pitteri: Department of Radiology, Stanford University
H. Tom Soh: Department of Radiology, Stanford University

DOI: https://doi.org/10.1038/s41467-021-26933-1
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 12

Abstract

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Glycosylation is an abundant form of post-translational modification. Here the authors present a generalizable workflow for the selection of indole-modified aptamers that can recognize protein glycoforms with high specificity.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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