Design and Synthesis of Two Bicyclo[3.3.1]nonane-steroid Derivatives

Abstract

This study describes the preparation of two bicyclo[3.3.3]nonane-steroid derivatives from either estradiol or estrone using some reactions such as etherification, addition, nucleophilic substitution and cyclization. The chemical structure was evaluated through NMR spectroscopic analysis. The results showed higher yield for 11 compared with 12. It is noteworthy that the reagents used in this investigation are not expensive and do not require special conditions for handling.

Keywords

• bicyclo
• steroid
• estrone derivative
• synthesis