Nature Communications (Nov 2022)
Elective nodal irradiation mitigates local and systemic immunity generated by combination radiation and immunotherapy in head and neck tumors
- Laurel B. Darragh,
- Jacob Gadwa,
- Tiffany T. Pham,
- Benjamin Van Court,
- Brooke Neupert,
- Nicholas A. Olimpo,
- Khoa Nguyen,
- Diemmy Nguyen,
- Michael W. Knitz,
- Maureen Hoen,
- Sophia Corbo,
- Molishree Joshi,
- Yonghua Zhuang,
- Maria Amann,
- Xiao-Jing Wang,
- Steven Dow,
- Ross M. Kedl,
- Von Samedi,
- Mary-Keara Boss,
- Sana D. Karam
Affiliations
- Laurel B. Darragh
- Department of Radiation Oncology, University of Colorado Denver at Anschutz Medical Campus
- Jacob Gadwa
- Department of Radiation Oncology, University of Colorado Denver at Anschutz Medical Campus
- Tiffany T. Pham
- Department of Otolaryngology Head and Neck Surgery, University of Colorado Denver at Anschutz Medical Campus
- Benjamin Van Court
- Department of Radiation Oncology, University of Colorado Denver at Anschutz Medical Campus
- Brooke Neupert
- Department of Radiation Oncology, University of Colorado Denver at Anschutz Medical Campus
- Nicholas A. Olimpo
- Department of Radiation Oncology, University of Colorado Denver at Anschutz Medical Campus
- Khoa Nguyen
- Department of Pathology, University of Colorado Denver at Anschutz Medical Campus
- Diemmy Nguyen
- Department of Radiation Oncology, University of Colorado Denver at Anschutz Medical Campus
- Michael W. Knitz
- Department of Radiation Oncology, University of Colorado Denver at Anschutz Medical Campus
- Maureen Hoen
- Department of Radiation Oncology, University of Colorado Denver at Anschutz Medical Campus
- Sophia Corbo
- Department of Radiation Oncology, University of Colorado Denver at Anschutz Medical Campus
- Molishree Joshi
- Department of Pharmacology, University of Colorado Denver at Anschutz Medical campus
- Yonghua Zhuang
- Department of Pediatrics, Cancer Center Biostatistics Core, University of Colorado Anschutz Medical campus
- Maria Amann
- Roche Innovation Center Zurich, Roche Pharmaceutical Research and Early Development (pRED) Schlieren
- Xiao-Jing Wang
- Department of Pathology and Laboratory Medicine, University of California Davis, School of Medicine
- Steven Dow
- Department of Radiation Oncology, Colorado State University, Fort Collins, Colorado. Campus
- Ross M. Kedl
- Department of Radiation Oncology, University of Colorado Denver at Anschutz Medical Campus
- Von Samedi
- Department of Pathology, University of Colorado Denver at Anschutz Medical Campus
- Mary-Keara Boss
- Department of Radiation Oncology, Colorado State University, Fort Collins, Colorado. Campus
- Sana D. Karam
- Department of Radiation Oncology, University of Colorado Denver at Anschutz Medical Campus
- DOI
- https://doi.org/10.1038/s41467-022-34676-w
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 18
Abstract
Neck dissection and/or elective nodal irradiation (ENI) are commonly performed in patients with head and neck squamous cell carcinoma (HNSCC) to minimize local and regional recurrence. However, here the authors show that ENI blunts the immune response to combined radiation and immunotherapy, increasing local and distant tumor growth in HNSCC preclinical models.
