Nature Communications (Apr 2019)

Phenotypes associated with genes encoding drug targets are predictive of clinical trial side effects

  • Phuong A. Nguyen,
  • David A. Born,
  • Aimee M. Deaton,
  • Paul Nioi,
  • Lucas D. Ward

DOI
https://doi.org/10.1038/s41467-019-09407-3
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 11

Abstract

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Safety issues including side effects are one of the major factors causing failure of clinical trials in drug development. Here, the authors leverage information about phenotypes associated with variation in genes encoding drug targets to predict drug-treatment-related side effects.