PREVALENCE OF MICROBIAL RESISTANCE TO CHLORHEXIDINE: A SYSTEMATIC REVIEW AND ANALYSIS OF REGIONAL MONITORING

Abstract

Aim. To determine microbial resistance to chlorhexidine. Materials and Methods. We performed a systematic review and analyzed the data from the regional monitoring of microbial resistance to chlorhexidine. Results. We found a substantial variability of the techniques to identify the microbial resistance to chlorhexidine. Furthermore, different studies demonstrated a significant heterogeneity regarding the prevalence of resistant strains (0,9 - 100,0% and 0,7 - 83,3%, average 21,3%) depending on the technique. Regional monitoring demonstrated a considerable microbial resistance to 0,5% aqueous solution of chlorhexidine [47,4% (95% CI = 37,2-57,6%)]. Conclusion. There is an urgent need in mechanistic studies on microbial resistance to chlorhexidine and in inclusion of this drug into the routine resistance monitoring in health facilities.

Keywords

• антисептик
• хлоргексидин
• устойчивость
• antiseptic
• chlorhexidine
• resistance