900 Depleting non-canonical, cell-intrinsic PD-L1 signals induces synthetic lethality to small molecule DNA damage response inhibitors in an immune independent and dependent manner

• Tyler Curiel,
• Lauren Byers,
• Yilun Deng,
• Alvaro Padron,
• Harshita Gupta,
• Anand Kornepati,
• Clare Murray,
• Ratna Vadlamudi,
• Barbara Avalos,
• Cody Rogers,
• Kavya Ramkumar,
• Zexuan Liu,
• Eloise Dray,
• Weixing Zhao,
• Patrick Sung

Affiliations

Tyler Curiel

UT Health San Antonio, San Antonio, TX, USA

Lauren Byers

The University of Texas MD Anderson Cancer Center, Houston, TX, USA

Yilun Deng

UT Health San Antonio, San Antonio, TX, USA

Alvaro Padron

1UT Health San Antonio, San Antonio, TX, USA

Harshita Gupta

UT Health San Antonio, San Antonio, TX, USA

Anand Kornepati

UT Health San Antonio, San Antonio, TX, USA

Clare Murray

Division of Infection, Immunity and Respiratory Medicine, The University of Manchester, Manchester, UK

Ratna Vadlamudi

2UTHSA, San Antonio, TX, USA

Barbara Avalos

1University of Texas Health Science Center San Antonio, San Antonio, TX, USA

Cody Rogers

1University of Texas Health Science Center San Antonio, San Antonio, TX, USA

Kavya Ramkumar

2UT MD Anderson, San Antonio, TX, USA

Zexuan Liu

1University of Texas Health Science Center San Antonio, San Antonio, TX, USA

Eloise Dray

1University of Texas Health Science Center San Antonio, San Antonio, TX, USA

Weixing Zhao

1University of Texas Health Science Center San Antonio, San Antonio, TX, USA

Patrick Sung

1University of Texas Health Science Center San Antonio, San Antonio, TX, USA