Case Reports in Oncology (May 2018)

Successful Treatment of Pulmonary Pleomorphic Carcinoma with Nivolumab: A Case Report

  • Eriko Fujimoto,
  • Takashi Yokoi,
  • Koji Mikami,
  • Shingo Kanemura,
  • Eisuke Shibata,
  • Daisuke Horio,
  • Yuichi Koda,
  • Yoshiki Negi,
  • Yumiko Akano,
  • Akio Tada,
  • Toshiyuki Minami,
  • Kozo Kuribayashi,
  • Takashi Kijima

DOI
https://doi.org/10.1159/000489392
Journal volume & issue
Vol. 11, no. 2
pp. 336 – 340

Abstract

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Pulmonary pleomorphic carcinoma (PPC) has a poor prognosis due to the poor results of treatment with systemic chemotherapy. We report the case of a 73-year-old woman with PPC who showed a favorable response to nivolumab. As first-line treatment for postoperative recurrence, she received carboplatin and nanoparticle albumin-bound paclitaxel. However, 12 months later, a new metastatic lymph node appeared. Nivolumab was administered as second-line treatment, and the patient showed a favorable prolonged response. The effects of treatment of PPC with nivolumab seem promising. The results of a future prospective study are expected to identify indicators for the treatment of PPC.

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