Percutaneous CT-Guided Bone Lesion Biopsy for Confirmation of Bone Metastases in Patients with Breast Cancer
Lucija Kovacevic,
Mislav Cavka,
Zlatko Marusic,
Elvira Kresic,
Andrija Stajduhar,
Lora Grbanovic,
Ivo Dumic-Cule,
Maja Prutki
Affiliations
Lucija Kovacevic
Clinical Department of Diagnostic and Interventional Radiology, University Hospital Center Zagreb School of Medicine, University of Zagreb, Kispaticeva 12, 10000 Zagreb, Croatia
Mislav Cavka
Clinical Department of Diagnostic and Interventional Radiology, University Hospital Center Zagreb School of Medicine, University of Zagreb, Kispaticeva 12, 10000 Zagreb, Croatia
Zlatko Marusic
Clinical Department of Pathology and Cytology, University Hospital Centre Zagreb, Kispaticeva 12, 10000 Zagreb, Croatia
Elvira Kresic
Clinical Department of Diagnostic and Interventional Radiology, University Hospital Center Zagreb School of Medicine, University of Zagreb, Kispaticeva 12, 10000 Zagreb, Croatia
Andrija Stajduhar
Department for Medical Statistics, Epidemiology and Medical Informatics School of Medicine, University of Zagreb, Salata 12, 10000 Zagreb, Croatia
Lora Grbanovic
Clinical Department of Diagnostic and Interventional Radiology, University Hospital Center Zagreb School of Medicine, University of Zagreb, Kispaticeva 12, 10000 Zagreb, Croatia
Ivo Dumic-Cule
Clinical Department of Diagnostic and Interventional Radiology, University Hospital Center Zagreb School of Medicine, University of Zagreb, Kispaticeva 12, 10000 Zagreb, Croatia
Maja Prutki
Clinical Department of Diagnostic and Interventional Radiology, University Hospital Center Zagreb School of Medicine, University of Zagreb, Kispaticeva 12, 10000 Zagreb, Croatia
We aimed to determine diagnostic accuracy of CT-guided bone lesion biopsy for the confirmation of bone metastases in patients with breast cancer and assessment of hormone receptor status in metastatic tissue. A total of 56 female patients with breast cancer that underwent CT-guided biopsy of suspected bone metastasis were enrolled in this retrospective study. Three different techniques were employed to obtain samples from various sites of skeleton. Collectively, 11 true negative and 3 false negative findings were revealed. The sensitivity of CT-guided biopsy for diagnosing bone metastases was 93.6%, specificity was 100% and accuracy was 94.8%. Discordance in progesterone receptor status and complete concordance in estrogen receptor status was observed. Based on our single-center experience, bone metastasis biopsy should be routinely performed in patients with breast cancer and suspicious bone lesions, due to the impact on further treatment.
