Nature Communications (Dec 2021)
Convergent use of phosphatidic acid for hepatitis C virus and SARS-CoV-2 replication organelle formation
- Keisuke Tabata,
- Vibhu Prasad,
- David Paul,
- Ji-Young Lee,
- Minh-Tu Pham,
- Woan-Ing Twu,
- Christopher J. Neufeldt,
- Mirko Cortese,
- Berati Cerikan,
- Yannick Stahl,
- Sebastian Joecks,
- Cong Si Tran,
- Christian Lüchtenborg,
- Philip V’kovski,
- Katrin Hörmann,
- André C. Müller,
- Carolin Zitzmann,
- Uta Haselmann,
- Jürgen Beneke,
- Lars Kaderali,
- Holger Erfle,
- Volker Thiel,
- Volker Lohmann,
- Giulio Superti-Furga,
- Britta Brügger,
- Ralf Bartenschlager
Affiliations
- Keisuke Tabata
- Department of Infectious Diseases, Molecular Virology, Heidelberg University
- Vibhu Prasad
- Department of Infectious Diseases, Molecular Virology, Heidelberg University
- David Paul
- Department of Infectious Diseases, Molecular Virology, Heidelberg University
- Ji-Young Lee
- Department of Infectious Diseases, Molecular Virology, Heidelberg University
- Minh-Tu Pham
- Department of Infectious Diseases, Molecular Virology, Heidelberg University
- Woan-Ing Twu
- Department of Infectious Diseases, Molecular Virology, Heidelberg University
- Christopher J. Neufeldt
- Department of Infectious Diseases, Molecular Virology, Heidelberg University
- Mirko Cortese
- Department of Infectious Diseases, Molecular Virology, Heidelberg University
- Berati Cerikan
- Department of Infectious Diseases, Molecular Virology, Heidelberg University
- Yannick Stahl
- Department of Infectious Diseases, Molecular Virology, Heidelberg University
- Sebastian Joecks
- Department of Infectious Diseases, Molecular Virology, Heidelberg University
- Cong Si Tran
- Department of Infectious Diseases, Molecular Virology, Heidelberg University
- Christian Lüchtenborg
- Biochemistry Center Heidelberg, Heidelberg University
- Philip V’kovski
- Institute of Virology and Immunology IVI
- Katrin Hörmann
- CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
- André C. Müller
- CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
- Carolin Zitzmann
- Institute of Bioinformatics and Center for Functional Genomics of Microbes, University Medicine Greifswald
- Uta Haselmann
- Department of Infectious Diseases, Molecular Virology, Heidelberg University
- Jürgen Beneke
- BioQuant, Heidelberg University
- Lars Kaderali
- Institute of Bioinformatics and Center for Functional Genomics of Microbes, University Medicine Greifswald
- Holger Erfle
- BioQuant, Heidelberg University
- Volker Thiel
- Institute of Virology and Immunology IVI
- Volker Lohmann
- Department of Infectious Diseases, Molecular Virology, Heidelberg University
- Giulio Superti-Furga
- CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
- Britta Brügger
- Biochemistry Center Heidelberg, Heidelberg University
- Ralf Bartenschlager
- Department of Infectious Diseases, Molecular Virology, Heidelberg University
- DOI
- https://doi.org/10.1038/s41467-021-27511-1
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 15
Abstract
Double membrane vesicles (DMV) are used as replication organelles by several RNA viruses. Applying proteomics and lipidomics, Tabata and Prasad et al. find that two cellular acyltransferases (AGPAT1/2), responsible for synthesis of phosphatidic acid, play a role in the DMV-biogenesis of HCV and SARS-CoV-2, highlighting a common biogenesis mechanism for evolutionary distant positive-strand RNA viruses.
