Accurate imputation of human leukocyte antigens with CookHLA

Seungho Cook; Wanson Choi; Hyunjoon Lim; Yang Luo; Kunhee Kim; Xiaoming Jia; Soumya Raychaudhuri; Buhm Han

doi:10.1038/s41467-021-21541-5

Nature Communications (Feb 2021)

Accurate imputation of human leukocyte antigens with CookHLA

Seungho Cook,
Wanson Choi,
Hyunjoon Lim,
Yang Luo,
Kunhee Kim,
Xiaoming Jia,
Soumya Raychaudhuri,
Buhm Han

Affiliations

Seungho Cook: Department of Biomedical Sciences, BK21 Plus Biomedical Science Project, Seoul National University College of Medicine
Wanson Choi: Department of Biomedical Sciences, BK21 Plus Biomedical Science Project, Seoul National University College of Medicine
Hyunjoon Lim: Interdisciplinary Program for Bioengineering, Seoul National University
Yang Luo: Center for Data Sciences, Brigham and Women’s Hospital and Harvard Medical School
Kunhee Kim: Department of Biomedical Sciences, BK21 Plus Biomedical Science Project, Seoul National University College of Medicine
Xiaoming Jia: Department of Neurology, University of California San Francisco
Soumya Raychaudhuri: Center for Data Sciences, Brigham and Women’s Hospital and Harvard Medical School
Buhm Han: Department of Biomedical Sciences, BK21 Plus Biomedical Science Project, Seoul National University College of Medicine

DOI: https://doi.org/10.1038/s41467-021-21541-5
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 11

Abstract

Read online

Human leukocyte antigen (HLA) genes influence many immune phenotypes, however methods to impute HLA type have been limited in accuracy. Here, the authors present an HLA imputation method, CookHLA, which uses locally embedded prediction markers to adaptively impute HLA genes across a range of scenarios.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal