Вопросы современной педиатрии (Dec 2013)

EFFICACY OF ETANERCEPT IN TREATMENT OF VARIOUS TYPES OF JUVENILE IDIOPATHIC ARTHRITIS

  • O. Yu. Konopel'ko,
  • E. S. Zholobova,
  • M. N. Nikolaeva,
  • O. S. Rozvadovskaya,
  • V. Ya. El'yashevich,
  • E. Yu. Afonina

DOI
https://doi.org/10.15690/vsp.v12i6.885
Journal volume & issue
Vol. 12, no. 6
pp. 115 – 119

Abstract

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Aim: to assess efficacy and safety of etanercept in treatment of various types of juvenile idiopathic arthritis in children under conditions of real clinical practice. Patients and methods: 52 children were included into the study, among them 16 were with systemic and 36 with juvenile idiopathic arthritis without extra-articular involvement. Results: etanercept treatment was the most efficient in patients with systemic juvenile idiopathic arthritis without extra-articular involvement. In 6 and 12 months of the treatment 50 and 70% improvement according to the ACRpedi criteria were established in 31/36 (86%) and 28/36 (78%) of the patients, respectively. In 24 months in 5 (29%) of 17 children remained in the study remission stage of the diseases was confirmed. Conclusions: etanercept treatment was not associated with significant unfavorable effects, which allows to recommend this drug for treatment of juvenile idiopathic arthritis without extra-articular involvent and resistant to standard anti-rheumatic therapy.

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