Nature Communications (Aug 2017)
Oropharyngeal mucosal transmission of Zika virus in rhesus macaques
- Christina M. Newman,
- Dawn M. Dudley,
- Matthew T. Aliota,
- Andrea M. Weiler,
- Gabrielle L. Barry,
- Mariel S. Mohns,
- Meghan E. Breitbach,
- Laurel M. Stewart,
- Connor R. Buechler,
- Michael E. Graham,
- Jennifer Post,
- Nancy Schultz-Darken,
- Eric Peterson,
- Wendy Newton,
- Emma L. Mohr,
- Saverio Capuano,
- David H. O’Connor,
- Thomas C. Friedrich
Affiliations
- Christina M. Newman
- Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health
- Dawn M. Dudley
- Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health
- Matthew T. Aliota
- Department of Pathobiological Sciences, University of Wisconsin School of Veterinary Medicine
- Andrea M. Weiler
- Wisconsin National Primate Research Center, University of Wisconsin
- Gabrielle L. Barry
- Wisconsin National Primate Research Center, University of Wisconsin
- Mariel S. Mohns
- Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health
- Meghan E. Breitbach
- Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health
- Laurel M. Stewart
- Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health
- Connor R. Buechler
- Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health
- Michael E. Graham
- Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health
- Jennifer Post
- Wisconsin National Primate Research Center, University of Wisconsin
- Nancy Schultz-Darken
- Wisconsin National Primate Research Center, University of Wisconsin
- Eric Peterson
- Wisconsin National Primate Research Center, University of Wisconsin
- Wendy Newton
- Wisconsin National Primate Research Center, University of Wisconsin
- Emma L. Mohr
- Department of Pediatrics, University of Wisconsin, University of Wisconsin Clinical Science Center
- Saverio Capuano
- Wisconsin National Primate Research Center, University of Wisconsin
- David H. O’Connor
- Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health
- Thomas C. Friedrich
- Department of Pathobiological Sciences, University of Wisconsin School of Veterinary Medicine
- DOI
- https://doi.org/10.1038/s41467-017-00246-8
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 7
Abstract
Zika virus (ZIKV) is present in body fluids, including saliva, but transmission risk through mucosal contact is not well known. Here, the authors show that oropharyngeal mucosal infection of macaques with a high ZIKV dose results in viremia, but that transmission risk from saliva of infected animals is low.
