Activation of STING requires palmitoylation at the Golgi

Kojiro Mukai; Hiroyasu Konno; Tatsuya Akiba; Takefumi Uemura; Satoshi Waguri; Toshihide Kobayashi; Glen N. Barber; Hiroyuki Arai; Tomohiko Taguchi

doi:10.1038/ncomms11932

Nature Communications (Jun 2016)

Activation of STING requires palmitoylation at the Golgi

Kojiro Mukai,
Hiroyasu Konno,
Tatsuya Akiba,
Takefumi Uemura,
Satoshi Waguri,
Toshihide Kobayashi,
Glen N. Barber,
Hiroyuki Arai,
Tomohiko Taguchi

Affiliations

Kojiro Mukai: Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
Hiroyasu Konno: Department of Cell Biology and Sylvester Comprehensive Cancer Center, University of Miami School of Medicine
Tatsuya Akiba: Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
Takefumi Uemura: Department of Anatomy and Histology, Fukushima Medical University School of Medicine, Hikarigaoka
Satoshi Waguri: Department of Anatomy and Histology, Fukushima Medical University School of Medicine, Hikarigaoka
Toshihide Kobayashi: Lipid Biology Laboratory, RIKEN
Glen N. Barber: Department of Cell Biology and Sylvester Comprehensive Cancer Center, University of Miami School of Medicine
Hiroyuki Arai: Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
Tomohiko Taguchi: Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan

DOI: https://doi.org/10.1038/ncomms11932
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 10

Abstract

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STING is essential for the type I interferon immune response to foreign DNA. Here, the authors show that palmitoylation of STING at the Golgi is required for activating downstream signalling, and increased Golgi localization of certain STING variants may cause autoimmune disease in some cases.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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