Nature Communications (Jun 2021)
The Atr-Chek1 pathway inhibits axon regeneration in response to Piezo-dependent mechanosensation
- Feng Li,
- Tsz Y. Lo,
- Leann Miles,
- Qin Wang,
- Harun N. Noristani,
- Dan Li,
- Jingwen Niu,
- Shannon Trombley,
- Jessica I. Goldshteyn,
- Chuxi Wang,
- Shuchao Wang,
- Jingyun Qiu,
- Katarzyna Pogoda,
- Kalpana Mandal,
- Megan Brewster,
- Panteleimon Rompolas,
- Ye He,
- Paul A. Janmey,
- Gareth M. Thomas,
- Shuxin Li,
- Yuanquan Song
Affiliations
- Feng Li
- Raymond G. Perelman Center for Cellular and Molecular Therapeutics, The Children’s Hospital of Philadelphia
- Tsz Y. Lo
- Raymond G. Perelman Center for Cellular and Molecular Therapeutics, The Children’s Hospital of Philadelphia
- Leann Miles
- The Graduate Group in Biochemistry and Molecular Biophysics, University of Pennsylvania
- Qin Wang
- Raymond G. Perelman Center for Cellular and Molecular Therapeutics, The Children’s Hospital of Philadelphia
- Harun N. Noristani
- Shriners Hospitals Pediatric Research Center (Center for Neurorehabilitation and Neural Repair), Temple University School of Medicine
- Dan Li
- Raymond G. Perelman Center for Cellular and Molecular Therapeutics, The Children’s Hospital of Philadelphia
- Jingwen Niu
- Shriners Hospitals Pediatric Research Center (Center for Neurorehabilitation and Neural Repair), Temple University School of Medicine
- Shannon Trombley
- Raymond G. Perelman Center for Cellular and Molecular Therapeutics, The Children’s Hospital of Philadelphia
- Jessica I. Goldshteyn
- Raymond G. Perelman Center for Cellular and Molecular Therapeutics, The Children’s Hospital of Philadelphia
- Chuxi Wang
- Raymond G. Perelman Center for Cellular and Molecular Therapeutics, The Children’s Hospital of Philadelphia
- Shuchao Wang
- Raymond G. Perelman Center for Cellular and Molecular Therapeutics, The Children’s Hospital of Philadelphia
- Jingyun Qiu
- Raymond G. Perelman Center for Cellular and Molecular Therapeutics, The Children’s Hospital of Philadelphia
- Katarzyna Pogoda
- Institute for Medicine and Engineering, University of Pennsylvania
- Kalpana Mandal
- Institute for Medicine and Engineering, University of Pennsylvania
- Megan Brewster
- Department of Dermatology, University of Pennsylvania
- Panteleimon Rompolas
- Department of Dermatology, University of Pennsylvania
- Ye He
- The City University of New York, Graduate Center - Advanced Science Research Center, Neuroscience Initiative
- Paul A. Janmey
- Institute for Medicine and Engineering, University of Pennsylvania
- Gareth M. Thomas
- Shriners Hospitals Pediatric Research Center (Center for Neurorehabilitation and Neural Repair), Temple University School of Medicine
- Shuxin Li
- Shriners Hospitals Pediatric Research Center (Center for Neurorehabilitation and Neural Repair), Temple University School of Medicine
- Yuanquan Song
- Raymond G. Perelman Center for Cellular and Molecular Therapeutics, The Children’s Hospital of Philadelphia
- DOI
- https://doi.org/10.1038/s41467-021-24131-7
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 20
Abstract
The Atr-Check1 pathway is involved in cell cycle and the DNA damage response. Here, the authors show that the Atr-Check1 pathway can inhibit axon regeneration in response to Piezo-mediated mechanosensation, affecting functional recovery.
