Nature Communications (Jun 2016)

Syndecan-4 negatively regulates antiviral signalling by mediating RIG-I deubiquitination via CYLD

  • Wei Lin,
  • Jing Zhang,
  • Haiyan Lin,
  • Zexing Li,
  • Xiaofeng Sun,
  • Di Xin,
  • Meng Yang,
  • Liwei Sun,
  • Lin Li,
  • Hongmei Wang,
  • Dahua Chen,
  • Qinmiao Sun

DOI
https://doi.org/10.1038/ncomms11848
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 15

Abstract

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Syndecans are transmembrane proteoglycans implicated in diverse cellular activities. Here the authors show that Syndecan-4 via its cytosolic domain negatively regulates antiviral immunity by enhancing RIG-I interaction with a deubiquitinating enzyme CYLD, thus inhibiting the activating K63-linked RIG-I ubiquitination.