INFECTIOUS TOXIC SHOCK IN TYPHOID FEVER DURING THE EPIDEMIC PERIOD AND AFTER IT

Abstract

Objective: To study the frequency and causes of the development of infectious toxic shock (ITS) in typhoid fever in military servants during the epidemic and the post-epidemic period. Methods: In 451 Military Hospital of the Russian Ministry of Defense (Dushanbe, Republic of Tajikistan) from 1995 up to 2009 were treated 837 military servants, hospitalized with a diagnosis of typhoid fever, of which 38 (4.54%) had ITS. The degree of endogenous intoxication and the parameters of the cardiovascular, respiratory and urinary systems evaluated. Results: It’s been identified during the epidemic, since (1996 to 1999) from 350 (41.8%) hospitalized patients in 20 (5.7%) and the post-epidemic period (2000-2009) out of 487 (58.2%) patients in 18 (3.6%) were diagnosed the ITS. The intensive therapy provided ITS relief and achieving a favorable outcome for all 38 patients. Conclusion: Thus, ITS which is one of the formidable complications of typhoid fever, was more frequently occurred in the epidemic period (5.7%), which coincided with the period of armed confrontation. In the post-epidemic period, which was on peacetime, its frequency was 3.6% of all hospitalized patients with typhoid fever.

Keywords

• typhoid fever
• complications
• infectious toxic shock
• epidemic period
• post-epidemic period.