Nature Communications (May 2018)

A self-destructive nanosweeper that captures and clears amyloid β-peptides

  • Qiang Luo,
  • Yao-Xin Lin,
  • Pei-Pei Yang,
  • Yi Wang,
  • Guo-Bin Qi,
  • Zeng-Ying Qiao,
  • Bing-Nan Li,
  • Kuo Zhang,
  • Jing-Ping Zhang,
  • Lei Wang,
  • Hao Wang

DOI
https://doi.org/10.1038/s41467-018-04255-z
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 12

Abstract

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Cerebral amyloid β-peptide accumulation is a causative factor in Alzheimer’s Disease. Here the authors design a 'nanosweeper' that binds amyloid β-peptide and induces autophagy to clear the accumulated plagues.