Nature Communications (Feb 2023)
Reproducing extracellular matrix adverse remodelling of non-ST myocardial infarction in a large animal model
- Paolo Contessotto,
- Renza Spelat,
- Federico Ferro,
- Vaidas Vysockas,
- Aušra Krivickienė,
- Chunsheng Jin,
- Sandrine Chantepie,
- Clizia Chinello,
- Audrys G. Pauza,
- Camilla Valente,
- Mindaugas Rackauskas,
- Alvise Casara,
- Vilma Zigmantaitė,
- Fulvio Magni,
- Dulce Papy-Garcia,
- Niclas G. Karlsson,
- Eglė Ereminienė,
- Abhay Pandit,
- Mark Da Costa
Affiliations
- Paolo Contessotto
- CÚRAM, SFI Research Centre for Medical Devices, University of Galway
- Renza Spelat
- CÚRAM, SFI Research Centre for Medical Devices, University of Galway
- Federico Ferro
- CÚRAM, SFI Research Centre for Medical Devices, University of Galway
- Vaidas Vysockas
- LSMU Biological Research Center, Lithuanian University of Health Sciences
- Aušra Krivickienė
- Department of Cardiology, Medical Academy, Lithuanian University of Health Sciences
- Chunsheng Jin
- Proteomics Core Facility at Sahlgrenska Academy, University of Gothenburg
- Sandrine Chantepie
- Glycobiology, Cell Growth and Tissue Repair Research Unit (Gly‑CRRET), University Paris Est Créteil
- Clizia Chinello
- Clinical Proteomics and Metabolomics Unit, School of Medicine and Surgery, University of Milano-Bicocca
- Audrys G. Pauza
- Institute of Anatomy, Lithuanian University of Health Sciences
- Camilla Valente
- Department of Molecular Medicine, University of Padova
- Mindaugas Rackauskas
- UF Health Heart and Vascular Hospital
- Alvise Casara
- Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova
- Vilma Zigmantaitė
- LSMU Biological Research Center, Lithuanian University of Health Sciences
- Fulvio Magni
- Clinical Proteomics and Metabolomics Unit, School of Medicine and Surgery, University of Milano-Bicocca
- Dulce Papy-Garcia
- Glycobiology, Cell Growth and Tissue Repair Research Unit (Gly‑CRRET), University Paris Est Créteil
- Niclas G. Karlsson
- Proteomics Core Facility at Sahlgrenska Academy, University of Gothenburg
- Eglė Ereminienė
- Department of Cardiology, Medical Academy, Lithuanian University of Health Sciences
- Abhay Pandit
- CÚRAM, SFI Research Centre for Medical Devices, University of Galway
- Mark Da Costa
- CÚRAM, SFI Research Centre for Medical Devices, University of Galway
- DOI
- https://doi.org/10.1038/s41467-023-36350-1
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 16
Abstract
The study of the pathophysiology and possible interventions for non-ST-segment elevation myocardial infarction is hindered by the lack of a reproducible pre-clinical model. Here, authors develop an ovine model to reproduce post-ischemic remodeling in non-ST myocardial infarction and reveal distinct complex sugar moieties in cellular membranes and extracellular matrix patterns in infarcted tissue.
