Frontiers in Medicine (Jul 2022)

Neurological Manifestations of SARS-CoV-2 Infection: Protocol for a Sub-analysis of the COVID-19 Critical Care Consortium Observational Study

  • Denise Battaglini,
  • Denise Battaglini,
  • Lavienraj Premraj,
  • Lavienraj Premraj,
  • Matthew Griffee,
  • Samuel Huth,
  • Samuel Huth,
  • Jonathon Fanning,
  • Jonathon Fanning,
  • Glenn Whitman,
  • Diego Bastos Porto,
  • Rakesh Arora,
  • Rakesh Arora,
  • Lucian Durham,
  • Eric Gnall,
  • Eric Gnall,
  • Marcelo Amato,
  • Virginie Williams,
  • Alexandre Noel,
  • Sabrina Araujo De Franca,
  • Gordan Samoukovic,
  • Bambang Pujo,
  • David Kent,
  • Eva Marwali,
  • Abdulrahman Al-Fares,
  • Abdulrahman Al-Fares,
  • Stephanie-Susanne Stecher,
  • Mauro Panigada,
  • Marco Giani,
  • Marco Giani,
  • Giuseppe Foti,
  • Giuseppe Foti,
  • Paolo Pelosi,
  • Paolo Pelosi,
  • Antonio Pesenti,
  • Antonio Pesenti,
  • Nicole Marie White,
  • Gianluigi Li Bassi,
  • Gianluigi Li Bassi,
  • Gianluigi Li Bassi,
  • Jacky Suen,
  • John F. Fraser,
  • John F. Fraser,
  • Chiara Robba,
  • Chiara Robba,
  • Sung-Min Cho

DOI
https://doi.org/10.3389/fmed.2022.930217
Journal volume & issue
Vol. 9

Abstract

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IntroductionNeurological manifestations and complications in coronavirus disease-2019 (COVID-19) patients are frequent. Prior studies suggested a possible association between neurological complications and fatal outcome, as well as the existence of potential modifiable risk factors associated to their occurrence. Therefore, more information is needed regarding the incidence and type of neurological complications, risk factors, and associated outcomes in COVID-19.MethodsThis is a pre-planned secondary analysis of the international multicenter observational study of the COVID-19 Critical Care Consortium (which collected data both retrospectively and prospectively from the beginning of COVID-19 pandemic) with the aim to describe neurological complications in critically ill COVID-19 patients and to assess the associated risk factors, and outcomes. Adult patients with confirmed COVID-19, admitted to Intensive Care Unit (ICU) will be considered for this analysis. Data collected in the COVID-19 Critical Care Consortium study includes patients' pre-admission characteristics, comorbidities, severity status, and type and severity of neurological complications. In-hospital mortality and neurological outcome were collected at discharge from ICU, and at 28-days.Ethics and DisseminationThe COVID-19 Critical Care Consortium main study and its amendments have been approved by the Regional Ethics Committee of participating sites. No further approval is required for this secondary analysis.Trial Registration NumberACTRN12620000421932.

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