Bulletin of Faculty of Pharmacy Cairo University (Jun 2015)

Biotransformation of furanocoumarins by Cunninghamella elegans

  • Ghada Ismail El-shahat Ali Attia,
  • Kamillia A. Abou-El-seoud,
  • Abdel-Rahim Sayed Ibrahim

DOI
https://doi.org/10.1016/j.bfopcu.2014.09.001
Journal volume & issue
Vol. 53, no. 1
pp. 1 – 4

Abstract

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Biotransformation of Furanocoumarins; psoralen (1), bergapten (2), xanthotoxin (3) and imperatorin (4) was explored by Cunninghamella elegans NRRL 1392, revealing the metabolism of psoralen (1) and bergapten (2) into bergaptol (5), while xanthotoxin (3) and imperatorin (4) were converted into xanthotoxol (6). On the other hand unexpected conversion of xanthotoxin (3) into 3,4 dihydroxanthotoxin (7) occurred. The structure of the isolated pure metabolites was established using physical and spectroscopic techniques including, melting points, IR, 1H NMR, 13C NMR and mass spectroscopy.

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