Quadruple Multiple Primary Malignancies: Early Detection of Second Primary Malignancy by Esophagogastroduodenoscopy/Colonoscopy Is Crucial for Patients with Classic Kaposi’s Sarcoma
Nobuyuki Maruyama,
Yuko Okubo,
Masato Umikawa,
Akiko Matsuzaki,
Akira Hokama,
Fusahiro Hirano,
Tessho Maruyama,
Kazuhide Nishihara,
Toshiyuki Nakasone,
Shoko Makishi,
Hiroyuki Nakamura,
Naoki Yoshimi
Affiliations
Nobuyuki Maruyama
Department of Oral and Maxillofacial Functional Rehabilitation, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903-0215, Japan
Yuko Okubo
Department of Dermatology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903-0215, Japan
Masato Umikawa
Department of Medical Biochemistry, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903-0215, Japan
Akiko Matsuzaki
Department of Pathology, Ryukyu University Hospital, 207 Uehara, Nishihara, Okinawa 903-0215, Japan
Akira Hokama
Department of Endoscopy, Ryukyu University Hospital, 207 Uehara, Nishihara, Okinawa 903-0215, Japan
Fusahiro Hirano
Department of Oral and Maxillofacial Surgery, Ryukyu University Hospital, 207 Uehara, Nishihara, Okinawa 903-0215, Japan
Tessho Maruyama
Molecular Microbiology Group, Tropical Biosphere Research Center, University of the Ryukyus, Senbaru 1, Nishihara, Okinawa 903-0213, Japan
Kazuhide Nishihara
Department of Oral and Maxillofacial Functional Rehabilitation, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903-0215, Japan
Toshiyuki Nakasone
Department of Oral and Maxillofacial Surgery, Ryukyu University Hospital, 207 Uehara, Nishihara, Okinawa 903-0215, Japan
Shoko Makishi
Department of Oral and Maxillofacial Functional Rehabilitation, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903-0215, Japan
Hiroyuki Nakamura
Department of Oral and Maxillofacial Functional Rehabilitation, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903-0215, Japan
Naoki Yoshimi
Department of Pathology, Ryukyu University Hospital, 207 Uehara, Nishihara, Okinawa 903-0215, Japan
Currently, Kaposi’s sarcoma (KS) is treated following the recommendations of international guidelines. These guidelines recommend esophagogastroduodenoscopy/colonoscopy for detecting multicentric KS of visceral lesions. Second primary malignancies (SPMs) are also a common KS complication; however, information on their detection and treatment is unfortunately not yet indicated in these guidelines. This paper reports on an 86-year-old man who suffered from quadruple primary malignancies: skin classic KS with colon adenocarcinoma, oral squamous cell carcinoma (maxilla), and well-differentiated stomach adenocarcinoma. Gastric cancer was incidentally detected during esophagogastroduodenoscopy, which was performed to detect visceral KS. We suggest that esophagogastroduodenoscopy/colonoscopy be routinely performed during the follow-up of patients with KS. As SPMs are crucial complications in patients with KS, these malignancies should be detected as early as possible.
