Repression of germline genes by PRC1.6 and SETDB1 in the early embryo precedes DNA methylation-mediated silencing

Kentaro Mochizuki; Jafar Sharif; Kenjiro Shirane; Kousuke Uranishi; Aaron B. Bogutz; Sanne M. Janssen; Ayumu Suzuki; Akihiko Okuda; Haruhiko Koseki; Matthew C. Lorincz

doi:10.1038/s41467-021-27345-x

Nature Communications (Dec 2021)

Repression of germline genes by PRC1.6 and SETDB1 in the early embryo precedes DNA methylation-mediated silencing

Kentaro Mochizuki,
Jafar Sharif,
Kenjiro Shirane,
Kousuke Uranishi,
Aaron B. Bogutz,
Sanne M. Janssen,
Ayumu Suzuki,
Akihiko Okuda,
Haruhiko Koseki,
Matthew C. Lorincz

Affiliations

Kentaro Mochizuki: Department of Medical Genetics, Life Sciences Institute, University of British Columbia
Jafar Sharif: Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences (IMS)
Kenjiro Shirane: Department of Medical Genetics, Life Sciences Institute, University of British Columbia
Kousuke Uranishi: Division of Biomedical Sciences, Research Center for Genomic Medicine, Saitama Medical University
Aaron B. Bogutz: Department of Medical Genetics, Life Sciences Institute, University of British Columbia
Sanne M. Janssen: Department of Medical Genetics, Life Sciences Institute, University of British Columbia
Ayumu Suzuki: Division of Biomedical Sciences, Research Center for Genomic Medicine, Saitama Medical University
Akihiko Okuda: Division of Biomedical Sciences, Research Center for Genomic Medicine, Saitama Medical University
Haruhiko Koseki: Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences (IMS)
Matthew C. Lorincz: Department of Medical Genetics, Life Sciences Institute, University of British Columbia

DOI: https://doi.org/10.1038/s41467-021-27345-x
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 15

Abstract

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Germline genes are repressed by DNA methylation and histone marks. Here, the authors show that specific germline genes hypomethylated pre-implantation are enriched for PRC1.6, H2AK119ub1 and H3K9me3, which coordinately repress their expression.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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