Nature Communications (Jun 2021)

Deciphering an AgRP-serotoninergic neural circuit in distinct control of energy metabolism from feeding

  • Yong Han,
  • Guobin Xia,
  • Dollada Srisai,
  • Fantao Meng,
  • Yanlin He,
  • Yali Ran,
  • Yang He,
  • Monica Farias,
  • Giang Hoang,
  • István Tóth,
  • Marcelo O. Dietrich,
  • Miao-Hsueh Chen,
  • Yong Xu,
  • Qi Wu

DOI
https://doi.org/10.1038/s41467-021-23846-x
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 16

Abstract

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Neuronal signaling has an important role in the regulation of energy expenditure and body weight, however, the underlying mechanisms are incompletely understood. Here, the authors report a AgRP-MC4R-serotonin expressing neuronal circuit that regulate energy expenditure without affecting feeding.