Nature Communications (Jan 2022)

Coding and regulatory variants are associated with serum protein levels and disease

  • Valur Emilsson,
  • Valborg Gudmundsdottir,
  • Alexander Gudjonsson,
  • Thorarinn Jonmundsson,
  • Brynjolfur G. Jonsson,
  • Mohd A. Karim,
  • Marjan Ilkov,
  • James R. Staley,
  • Elias F. Gudmundsson,
  • Lenore J. Launer,
  • Jan H. Lindeman,
  • Nicholas M. Morton,
  • Thor Aspelund,
  • John R. Lamb,
  • Lori L. Jennings,
  • Vilmundur Gudnason

DOI
https://doi.org/10.1038/s41467-022-28081-6
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 11

Abstract

Read online

Finding the genetic basis of protein expression can elucidate the genetic mechanisms of disease. Here, the authors link low-frequency and common DNA sequence variants to thousands of serum proteins, finding genetic overlap between circulating proteins and a wide range of common diseases.