MedComm (Nov 2024)
Prognostic impact of age on outcomes of hepatic decompensation in patients with compensated cirrhosis (CHESS2102): an international, multicenter cohort study
- Shanghao Liu,
- Jia Li,
- Yujun Wong,
- Hyung Joon Yim,
- Masashi Hirooka,
- Hirayuki Enomoto,
- Qing Xie,
- Erhei Dai,
- Amr Shaaban Hanafy,
- Zhujun Cao,
- Lili Zhao,
- Kok Ban Teh,
- Tae Hyung Kim,
- Young Kul Jung,
- Yohei Koizumi,
- Yoichi Hiasa,
- Takashi Nishimura,
- Hiroko Iijima,
- Qingyi Tian,
- Xinru Guo,
- Yansheng Jia,
- Jinfang Sun,
- Chuan Liu,
- Xiaolong Qi
Affiliations
- Shanghao Liu
- Liver Disease Center of Integrated Traditional Chinese and Western Medicine Department of Radiology Zhongda Hospital Medical School Southeast University Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging & Interventional Radiology (Southeast University) Nanjing China
- Jia Li
- Department of Gastroenterology and Hepatology Tianjin Second People's Hospital Tianjin China
- Yujun Wong
- Department of Gastroenterology & Hepatology Changi General Hospital SingHealth Singapore Singapore
- Hyung Joon Yim
- Division of Gastroenterology and Hepatology Korea University Ansan Hospital Ansan Gyeonggi Republic of Korea
- Masashi Hirooka
- Department of Gastroenterology and Metabology Ehime University Graduate School of Medicine Ehime Japan
- Hirayuki Enomoto
- Division of Hepatobiliary and Pancreatic Diseases Department of Gastroenterology Hyogo Medical University Nishinomiya Japan
- Qing Xie
- Department of Infectious Disease Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China
- Erhei Dai
- Division of Liver Diseases The Fifth Hospital of Shijiazhuang North China University of Science and Technology Shijiazhuang China
- Amr Shaaban Hanafy
- Division of Gastroenterology Hepatology and Endoscopy Internal Medicine Zagazig University Faculty of Medicine Zagazig Egypt
- Zhujun Cao
- Department of Infectious Disease Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China
- Lili Zhao
- Department of Gastroenterology and Hepatology Tianjin Second People's Hospital Tianjin China
- Kok Ban Teh
- Department of Gastroenterology & Hepatology Changi General Hospital SingHealth Singapore Singapore
- Tae Hyung Kim
- Division of Gastroenterology and Hepatology Korea University Ansan Hospital Ansan Gyeonggi Republic of Korea
- Young Kul Jung
- Division of Gastroenterology and Hepatology Korea University Ansan Hospital Ansan Gyeonggi Republic of Korea
- Yohei Koizumi
- Department of Gastroenterology and Metabology Ehime University Graduate School of Medicine Ehime Japan
- Yoichi Hiasa
- Department of Gastroenterology and Metabology Ehime University Graduate School of Medicine Ehime Japan
- Takashi Nishimura
- Department of Internal Medicine Division of Gastroenterology and Hepatology Hyogo Medical University Nishinomiya Japan
- Hiroko Iijima
- Department of Internal Medicine Division of Gastroenterology and Hepatology Hyogo Medical University Nishinomiya Japan
- Qingyi Tian
- Liver Disease Center of Integrated Traditional Chinese and Western Medicine Department of Radiology Zhongda Hospital Medical School Southeast University Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging & Interventional Radiology (Southeast University) Nanjing China
- Xinru Guo
- Division of Liver Diseases The Fifth Hospital of Shijiazhuang North China University of Science and Technology Shijiazhuang China
- Yansheng Jia
- Division of Liver Diseases The Fifth Hospital of Shijiazhuang North China University of Science and Technology Shijiazhuang China
- Jinfang Sun
- Department of Epidemiology and Biostatistics School of Public Health Southeast University Nanjing China
- Chuan Liu
- Liver Disease Center of Integrated Traditional Chinese and Western Medicine Department of Radiology Zhongda Hospital Medical School Southeast University Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging & Interventional Radiology (Southeast University) Nanjing China
- Xiaolong Qi
- Liver Disease Center of Integrated Traditional Chinese and Western Medicine Department of Radiology Zhongda Hospital Medical School Southeast University Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging & Interventional Radiology (Southeast University) Nanjing China
- DOI
- https://doi.org/10.1002/mco2.781
- Journal volume & issue
-
Vol. 5,
no. 11
pp. n/a – n/a
Abstract
Abstract Baveno VII criteria (B7C) and Baveno VI criteria (B6C) have been widely used to estimate the risk of hepatic decompensation. However, the impact of age on these criteria warrants further investigation. The international, multicenter cohort study included 1138 patients with compensated cirrhosis (median follow‐up of 40.6 months), aiming to evaluate the value of age in predicting hepatic decompensation. We identified age as an independent predictor of hepatic decompensation, with 60 years determined as the optimal cut‐off value. The occurrence of decompensation was 18.7% and 6.7% in the older (age ≥60 years) and younger (age 0.05). In conclusion, our study demonstrated that integrating age into the Baveno criteria could enhance the assessment of hepatic decompensation. Age should be considered before discharging patients with compensated cirrhosis from the surveillance of hepatic decompensation.
Keywords
