Data supporting the angiotensin II activates MEL18 to deSUMOylate HSF2 for hypertension-related heart failure
Chih-Yang Huang,
Chia-Hua Kuo,
Pei-Ying Pai,
Tsung-Jung Ho,
Yueh-Min Lin,
Ray-Jade Chen,
Fuu-Jen Tsai,
V. Vijaya Padma,
Wei-Wen Kuo,
Chih-Yang Huang
Affiliations
Chih-Yang Huang
Translation Research Core, China Medical University Hospital, China Medical University, Taichung, Taiwan
Chia-Hua Kuo
Department of Sports Sciences, University of Taipei, Taipei, Taiwan
Pei-Ying Pai
Division of Cardiology, China Medical University Hospital, Taichung, Taiwan
Tsung-Jung Ho
School of Chinese Medicine, China Medical University, Taichung, Taiwan; Chinese Medicine Department, China Medical University Beigang Hospital, Taiwan
Yueh-Min Lin
Department of pathology, Changhua Christian Hospital, Changhua, Taiwan; Department of Medical Technology, Jen-Teh Junior College of Medicine, Nursing and Management, Miaoli, Taiwan
Ray-Jade Chen
Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
Fuu-Jen Tsai
School of Chinese Medicine, China Medical University, Taichung, Taiwan
V. Vijaya Padma
Department of Biotechnology, Bharathiar University, Coimbatore 641046, India
Wei-Wen Kuo
Department of Biological Science and Technology, China Medical University, Taichung, Taiwan
Chih-Yang Huang
School of Chinese Medicine, China Medical University, Taichung, Taiwan; Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan; Department of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan; Corresponding author at: Graduate Institute of Basic Medical Science, China Medical University, Taichung 40402, Taiwan.
In association with the published article “Inhibition of HSF2 SUMOylation via MEL18 upregulates IGF-IIR and leads to hypertension-induced cardiac hypertrophy” (Huang et al., 2017) [1], this data article contains information about deSUMOylation of HSF2 on lysine 82 on angiotensin II (ANG II) -induced cardiac hypertrophy, which is mediated by MEL18. Isolated adult human whole heart tissue showed MEL18-mediated HSF2-IGF-IIR pathway is upregulated in hypertension human heart, compared to health human heart.
