Erythropoietin Action in Stress Response,  Tissue Maintenance and Metabolism

Yuanyuan Zhang; Li Wang; Soumyadeep Dey; Mawadda Alnaeeli; Sukanya Suresh; Heather Rogers; Ruifeng Teng; Constance Tom Noguchi

doi:10.3390/ijms150610296

International Journal of Molecular Sciences (Jun 2014)

Erythropoietin Action in Stress Response, Tissue Maintenance and Metabolism

Yuanyuan Zhang,
Li Wang,
Soumyadeep Dey,
Mawadda Alnaeeli,
Sukanya Suresh,
Heather Rogers,
Ruifeng Teng,
Constance Tom Noguchi

Affiliations

Yuanyuan Zhang: Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Li Wang: Faculty of Health Sciences, University of Macau, Macau SAR, China
Soumyadeep Dey: Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Mawadda Alnaeeli: Department of Biological Sciences, Ohio University, Zanesville, OH 43701, USA
Sukanya Suresh: Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Heather Rogers: Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Ruifeng Teng: Mouse Metabolism Core Laboratory, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Constance Tom Noguchi: Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA

DOI: https://doi.org/10.3390/ijms150610296
Journal volume & issue: Vol. 15, no. 6
pp. 10296 – 10333

Abstract

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Erythropoietin (EPO) regulation of red blood cell production and its induction at reduced oxygen tension provides for the important erythropoietic response to ischemic stress. The cloning and production of recombinant human EPO has led to its clinical use in patients with anemia for two and half decades and has facilitated studies of EPO action. Reports of animal and cell models of ischemic stress in vitro and injury suggest potential EPO benefit beyond red blood cell production including vascular endothelial response to increase nitric oxide production, which facilitates oxygen delivery to brain, heart and other non-hematopoietic tissues. This review discusses these and other reports of EPO action beyond red blood cell production, including EPO response affecting metabolism and obesity in animal models. Observations of EPO activity in cell and animal model systems, including mice with tissue specific deletion of EPO receptor (EpoR), suggest the potential for EPO response in metabolism and disease.

Published in International Journal of Molecular Sciences

ISSN: 1661-6596 (Print); 1422-0067 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General); Science: Chemistry
Website: http://www.mdpi.com/journal/ijms

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