Journal of Inflammation Research (Aug 2020)
Recent Updates on Anti-Inflammatory and Antimicrobial Effects of Furan Natural Derivatives
Abstract
Mohammad Alizadeh,1,* Moludi Jalal,2 Khodaei Hamed,3 Amir Saber,2,* Sorayya Kheirouri,1 Fatemeh Pourteymour Fard Tabrizi,3 Negin Kamari2 1Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; 2Department of Nutritional Sciences, School of Nutritional Sciences and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran; 3Department of Biochemistry and Diet Therapy, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran*These authors contributed equally to this workCorrespondence: Moludi JalalDepartment of Nutrition, School of Nutritional Sciences and Food Technologies, Kermanshah University of Medical Sciences, Isar Sq., Across from Farabi Hospital, Kermanshah, IranTel +98-83 37102009Fax +98-83 37102002Email [email protected] HamedDepartment of Biochemistry and Diet Therapy, Faculty of Nutrition, Tabriz University of Medical Sciences, Daneshgah Street, Tabriz, IranEmail [email protected]: The furan nucleus is found in a large number of biologically active materials. In recent years, many natural furan derivatives were isolated and their biological effects were investigated. In this review, we focused on the anti-inflammatory and antimicrobial effects of some natural furans and discussed their effects on the immune system. Our investigation revealed that furan natural derivatives have effective antioxidant activities and exert regulatory effects on various cellular activities by modifying some signaling pathways such as MAPK (mitogen-activated Protein Kinase) and PPAR-ɣ (peroxisome proliferator-activated receptor gamma). The antimicrobial activity of these natural compounds was performed through selective inhibition of microbial growth and modification of enzymes. Further studies are needed for isolation and detection of different furan derivatives from natural compounds and investigation of their precise mechanisms for revealing health beneficial effects of these compounds.Keywords: anti-inflammatory, antimicrobial, furans, benzofurans, furan natural derivatives
