Elucidation of the Role of SMAD4 in Epithelial–Mesenchymal Plasticity: Does It Help to Better Understand the Consequences of <i>DPC4</i> Inactivation in the Malignant Progression of Pancreatic Ductal Adenocarcinoma?

Hendrik Ungefroren; Björn Konukiewitz; Rüdiger Braun; Ulrich Friedrich Wellner; Tobias Keck; Jens-Uwe Marquardt

doi:10.3390/cancers15030581

Cancers (Jan 2023)

Elucidation of the Role of SMAD4 in Epithelial–Mesenchymal Plasticity: Does It Help to Better Understand the Consequences of <i>DPC4</i> Inactivation in the Malignant Progression of Pancreatic Ductal Adenocarcinoma?

Hendrik Ungefroren,
Björn Konukiewitz,
Rüdiger Braun,
Ulrich Friedrich Wellner,
Tobias Keck,
Jens-Uwe Marquardt

Affiliations

Hendrik Ungefroren: First Department of Medicine, University Hospital Schleswig-Holstein (UKSH), Campus Lübeck, D-23538 Lübeck, Germany
Björn Konukiewitz: Institute of Pathology, University Hospital Schleswig-Holstein, Campus Kiel, D-24105 Kiel, Germany
Rüdiger Braun: Department of Surgery, University Hospital Schleswig-Holstein, Campus Lübeck, D-23538 Lübeck, Germany
Ulrich Friedrich Wellner: Department of Surgery, University Hospital Schleswig-Holstein, Campus Lübeck, D-23538 Lübeck, Germany
Tobias Keck: Department of Surgery, University Hospital Schleswig-Holstein, Campus Lübeck, D-23538 Lübeck, Germany
Jens-Uwe Marquardt: First Department of Medicine, University Hospital Schleswig-Holstein (UKSH), Campus Lübeck, D-23538 Lübeck, Germany

DOI: https://doi.org/10.3390/cancers15030581
Journal volume & issue: Vol. 15, no. 3
p. 581

Abstract

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Pancreatic ductal adenocarcinoma (PDAC) is the 4th leading cause of cancer-related mortality worldwide, with a 5-year-survival rate below 10% that is the lowest of all cancer types [...]

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Published in Cancers

ISSN: 2072-6694 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.mdpi.com/journal/cancers/

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Abstract

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