Nature Communications (May 2017)
Lipoprotein-biomimetic nanostructure enables efficient targeting delivery of siRNA to Ras-activated glioblastoma cells via macropinocytosis
- Jia-Lin Huang,
- Gan Jiang,
- Qing-Xiang Song,
- Xiao Gu,
- Meng Hu,
- Xiao-Lin Wang,
- Hua-Hua Song,
- Le-Pei Chen,
- Ying-Ying Lin,
- Di Jiang,
- Jun Chen,
- Jun-Feng Feng,
- Yong-Ming Qiu,
- Ji-Yao Jiang,
- Xin-Guo Jiang,
- Hong-Zhuan Chen,
- Xiao-Ling Gao
Affiliations
- Jia-Lin Huang
- Department of Pharmacology, Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine
- Gan Jiang
- Department of Pharmacology, Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine
- Qing-Xiang Song
- Department of Pharmacology, Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine
- Xiao Gu
- Department of Pharmacology, Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine
- Meng Hu
- Department of Pharmacology, Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine
- Xiao-Lin Wang
- Department of Pharmacology, Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine
- Hua-Hua Song
- Department of Pharmacology, Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine
- Le-Pei Chen
- Department of Pharmacology, Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine
- Ying-Ying Lin
- Department of Neurological Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University
- Di Jiang
- Department of Pharmaceutics, Key Laboratory of Smart Drug Delivery, Ministry of Education & PLA, School of Pharmacy, Fudan University
- Jun Chen
- Department of Pharmaceutics, Key Laboratory of Smart Drug Delivery, Ministry of Education & PLA, School of Pharmacy, Fudan University
- Jun-Feng Feng
- Department of Neurological Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University
- Yong-Ming Qiu
- Department of Neurological Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University
- Ji-Yao Jiang
- Department of Neurological Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University
- Xin-Guo Jiang
- Department of Pharmaceutics, Key Laboratory of Smart Drug Delivery, Ministry of Education & PLA, School of Pharmacy, Fudan University
- Hong-Zhuan Chen
- Department of Pharmacology, Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine
- Xiao-Ling Gao
- Department of Pharmacology, Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine
- DOI
- https://doi.org/10.1038/ncomms15144
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 18
Abstract
Drug delivery in brain tumours is still a significant clinical concern. In this study, the authors develop a biomimetic lipoprotein nanoparticle for the efficient delivery of ATF5 siRNA inRas-activated brain cancer cells, where the nanoparticle is internalized by macropinocytosis in a Ras-dependent manner.
