Circ-CSNK1G1 promotes cell proliferation, migration, invasion and glycolysis metabolism during triple-negative breast cancer progression by modulating the miR-28-5p/LDHA pathway

Xiaochen Zan; Wenfang Li; Geng Wang; Jie Yuan; Yongbiao Ai; Jun Huang; Zhi Li

doi:10.1186/s12958-022-00998-z

Reproductive Biology and Endocrinology (Sep 2022)

Circ-CSNK1G1 promotes cell proliferation, migration, invasion and glycolysis metabolism during triple-negative breast cancer progression by modulating the miR-28-5p/LDHA pathway

Xiaochen Zan,
Wenfang Li,
Geng Wang,
Jie Yuan,
Yongbiao Ai,
Jun Huang,
Zhi Li

Affiliations

Xiaochen Zan: Department of General Surgery, Taihe Hospital, Huibei University of Medicine
Wenfang Li: Department of General Surgery, Taihe Hospital, Huibei University of Medicine
Geng Wang: Department of General Surgery, Taihe Hospital, Huibei University of Medicine
Jie Yuan: Department of General Surgery, Taihe Hospital, Huibei University of Medicine
Yongbiao Ai: Department of General Surgery, Taihe Hospital, Huibei University of Medicine
Jun Huang: Department of General Surgery, Taihe Hospital, Huibei University of Medicine
Zhi Li: Department of General Surgery, Taihe Hospital, Huibei University of Medicine

DOI: https://doi.org/10.1186/s12958-022-00998-z
Journal volume & issue: Vol. 20, no. 1
pp. 1 – 14

Abstract

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Highlights 1. Circ-CSNK1G1 is upregulated in TNBC. 2. Circ-CSNK1G1 knockdown inhibits the proliferation, migration, invasion and glycolysis energy metabolism of TNBC cells. 3. Circ-CSNK1G1 knockdown inhibits tumor formation in vivo. 4. Circ-CSNK1G1 promotes TNBC development by regulating the miR-28-5p/LDHA pathway.

Published in Reproductive Biology and Endocrinology

ISSN: 1477-7827 (Online)
Publisher: BMC
Country of publisher: United Kingdom
LCC subjects: Medicine: Gynecology and obstetrics; Science: Biology (General): Reproduction
Website: https://rbej.biomedcentral.com/

About the journal

Abstract

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