In vitro Activity of Contezolid Against Methicillin-Resistant Staphylococcus aureus, Vancomycin-Resistant Enterococcus, and Strains With Linezolid Resistance Genes From China

Siheng Wang; Chang Cai; Yingbo Shen; Chengtao Sun; Qingxin Shi; Ningjun Wu; Shufang Zheng; Jiao Qian; Rong Zhang; Hongwei Zhou

doi:10.3389/fmicb.2021.729900

Frontiers in Microbiology (Aug 2021)

In vitro Activity of Contezolid Against Methicillin-Resistant Staphylococcus aureus, Vancomycin-Resistant Enterococcus, and Strains With Linezolid Resistance Genes From China

Siheng Wang,
Chang Cai,
Yingbo Shen,
Chengtao Sun,
Qingxin Shi,
Ningjun Wu,
Shufang Zheng,
Jiao Qian,
Rong Zhang,
Hongwei Zhou

Affiliations

Siheng Wang: Clinical Microbiology Laboratory, The Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, China
Chang Cai: China Australia Joint Laboratory for Animal Health Big Data Analytics, College of Animal Science and Technology, Zhejiang Agricultural and Forestry University, Hangzhou, China
Yingbo Shen: Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing, China
Chengtao Sun: Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing, China
Qingxin Shi: Clinical Laboratory Department, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, China
Ningjun Wu: Clinical Laboratory, Lishui People’s Hospital, Lishui, China
Shufang Zheng: Department of Laboratory Medicine, Jinhua People’s Hospital, Jinhua, China
Jiao Qian: Clinical Laboratory Department, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, China
Rong Zhang: Clinical Microbiology Laboratory, The Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, China
Hongwei Zhou: Clinical Microbiology Laboratory, The Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, China

DOI: https://doi.org/10.3389/fmicb.2021.729900
Journal volume & issue: Vol. 12

Abstract

Read online

Contezolid is a novel oxazolidinone, which exhibits potent activity against gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus (VRE), and penicillin-resistant Streptococcus pneumoniae (PRSP). In this study, the in vitro activity of contezolid was compared with linezolid (LZD), tigecycline (TGC), teicoplanin (TEC), vancomycin (VA), daptomycin (DAP), and florfenicol (FFC) against MRSA and VRE strains isolated from China. Contezolid revealed considerable activity against MRSA and VRE isolates with MIC90 values of 0.5 and 1.0 μg/mL, respectively. For VRE strains with different resistance genotypes, including vanA- and vanM-type strains, contezolid did not exhibit significantly differential antibacterial activity. Furthermore, the antimicrobial activity of contezolid is similar to or slightly better than that of linezolid against MRSA and VRE strains. Subsequently, the activity of contezolid was tested against strains carrying linezolid resistance genes, including Staphylococcus capitis carrying cfr gene and Enterococcus faecalis carrying optrA gene. The results showed that contezolid exhibited similar antimicrobial efficacy to linezolid against strains with linezolid resistance genes. In general, contezolid may have potential benefits to treat the infections caused by MRSA and VRE pathogens.

Published in Frontiers in Microbiology

ISSN: 1664-302X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Microbiology
Website: http://www.frontiersin.org/journals/microbiology

About the journal

Abstract

Keywords