Study on the correlation between mineral bone metabolism and CRP in patients with SHPT during perioperative period

Abstract

Abstract Objective This study mainly observes changes in perioperative mineral bone metabolism‐related indicators and inflammatory factors in patients with secondary hyperparathyroidism (SHPT), and analyzed the correlation between mineral bone metabolism‐related indicators and inflammatory factors. Methods Clinical data were collected. The study detects mineral bone metabolism‐related indicators and inflammatory factor of perioperative patients with SHPT before and 4 days after operation. The production of high‐sensitivity c‐reactive protein (hs‐CRP) in human hepatocytes cells (LO2 cells) stimulated by different concentrations of parathyroid hormone‐associated protein was detected by enzyme‐linked immunosorbent assay, reverse‐transcription polymerase chain reaction (RT‐PCR), and western blot. Results The levels of mineral bone metabolism‐related indicators and hs‐CRP in SHPT group were significantly higher than those of control group. After operation, serum calcium, serum phosphorus, iPTH, FGF‐23 decreased, and the level of osteoblast active biomarkers increased, while the level of osteoclast active biomarkers decreased. The levels of hs‐CRP decreased significantly after operation. With the increase of PTHrP concentration, hs‐CRP level in supernatant of LO2 cells decreased first and then increased. RT‐PCR and western blot shows the same trend. Conclusion Parathyroidectomy can significantly improve bone resorption and inflammation in SHPT patients. We speculate that there may be an optimal range of PTH concentrations to minimize inflammation in the body.

Keywords

• chronic kidney disease
• inflammation
• mineral bone metabolism disorders
• parathyroidectomy
• secondary hyperparathyroidism