Effect of metformin and antioxidant agents on oxidative stress status and follicular maturation in women with polycystic ovary syndrome

Abstract

In this study, forty-two Iraqi Arab Women with PCOS were involved and they were classified into three groups according to type of treatment: 1) Group І: fourteen patients who administered metformin (500mg t.i.d). 2) Group П: fourteen patients who administered combination of metformin (500mg t.i.d) with vitamin C (250mg t.i.d) 3) Group PI: fourteen patients who administered combination of metformin (500mg t.i.d) with vitamin E (200mg t.i.d).All groups were treated for three months . The present study includes the measurement of serum malondialdehyde, Vitamin E and its metabolite (tocopheronic acid) play an important role in alleviation of oxidative stress(MDA) and may potentiate the metformin activity in maturation of follicles