Nature Communications (Sep 2022)

MTG8 interacts with LHX6 to specify cortical interneuron subtype identity

  • Zeinab Asgarian,
  • Marcio Guiomar Oliveira,
  • Agata Stryjewska,
  • Ioannis Maragkos,
  • Anna Noren Rubin,
  • Lorenza Magno,
  • Vassilis Pachnis,
  • Mohammadmersad Ghorbani,
  • Scott Wayne Hiebert,
  • Myrto Denaxa,
  • Nicoletta Kessaris

DOI
https://doi.org/10.1038/s41467-022-32898-6
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 15

Abstract

Read online

There is a large diversity of inhibitory interneurons in the mammalian cerebral cortex. How this emerges during embryogenesis remains unclear. Here, the authors identify MTG8 as a co-factor of LHX6 and a new regulator of cortical interneuron development.