Regulatory T cells promote cancer immune-escape through integrin αvβ8-mediated TGF-β activation

Alexandra Lainé; Ossama Labiad; Hector Hernandez-Vargas; Sébastien This; Amélien Sanlaville; Sophie Léon; Stéphane Dalle; Dean Sheppard; Mark A. Travis; Helena Paidassi; Julien C. Marie

doi:10.1038/s41467-021-26352-2

Nature Communications (Oct 2021)

Regulatory T cells promote cancer immune-escape through integrin αvβ8-mediated TGF-β activation

Alexandra Lainé,
Ossama Labiad,
Hector Hernandez-Vargas,
Sébastien This,
Amélien Sanlaville,
Sophie Léon,
Stéphane Dalle,
Dean Sheppard,
Mark A. Travis,
Helena Paidassi,
Julien C. Marie

Affiliations

Alexandra Lainé: Tumor Escape Resistance and Immunity department, Cancer Research Center of Lyon INSERM U1052, CNRS UMR 5286, Centre Léon Bérard, Claude Bernard Université Lyon 1
Ossama Labiad: Tumor Escape Resistance and Immunity department, Cancer Research Center of Lyon INSERM U1052, CNRS UMR 5286, Centre Léon Bérard, Claude Bernard Université Lyon 1
Hector Hernandez-Vargas: Tumor Escape Resistance and Immunity department, Cancer Research Center of Lyon INSERM U1052, CNRS UMR 5286, Centre Léon Bérard, Claude Bernard Université Lyon 1
Sébastien This: CIRI, Centre International de Recherche en Infectiologie, Université de Lyon, INSERM U1111, Université Claude Bernard Lyon 1, CNRS UMR5308, ENS de Lyon
Amélien Sanlaville: Tumor Escape Resistance and Immunity department, Cancer Research Center of Lyon INSERM U1052, CNRS UMR 5286, Centre Léon Bérard, Claude Bernard Université Lyon 1
Sophie Léon: Plateforme Ex-Vivo, Département de Recherche Translationnelle et d’Innovation, Centre Léon Bérard
Stéphane Dalle: Tumor Escape Resistance and Immunity department, Cancer Research Center of Lyon INSERM U1052, CNRS UMR 5286, Centre Léon Bérard, Claude Bernard Université Lyon 1
Dean Sheppard: University of California San Francisco
Mark A. Travis: Lydia Becker Institute of Immunology and Inflammation, University of Manchester
Helena Paidassi: CIRI, Centre International de Recherche en Infectiologie, Université de Lyon, INSERM U1111, Université Claude Bernard Lyon 1, CNRS UMR5308, ENS de Lyon
Julien C. Marie: Tumor Escape Resistance and Immunity department, Cancer Research Center of Lyon INSERM U1052, CNRS UMR 5286, Centre Léon Bérard, Claude Bernard Université Lyon 1

DOI: https://doi.org/10.1038/s41467-021-26352-2
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 14

Abstract

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TGFβ is secreted in an inactive form in the tumor microenvironment. Authors here show that although TGFβ is produced mainly by cancer cells, regulatory T cells are necessary for its activation via expression of the b8 chain of avb8 integrin. Thus, both cell types contribute to TGFβ dependent tumor growth.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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