mBio
(Jun 2021)
The
<i>Toxoplasma</i>
Polymorphic Effector GRA15 Mediates Seizure Induction by Modulating Interleukin-1 Signaling in the Brain
Taylor G. Glausen,
Gabriela L. Carrillo,
Richard M. Jin,
Jon P. Boyle,
Jeroen P. J. Saeij,
Elizabeth A. Wohlfert,
Michael A. Fox,
Ira J. Blader
Affiliations
Taylor G. Glausen
Department of Microbiology and Immunology, SUNY at Buffalo School of Medicine, Buffalo, New York, USA
Gabriela L. Carrillo
Center for Neurobiology Research, Fralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, Virginia, USA
Richard M. Jin
Department of Microbiology and Immunology, SUNY at Buffalo School of Medicine, Buffalo, New York, USA
Jon P. Boyle
Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Jeroen P. J. Saeij
ORCiD Department of Pathology, Microbiology, and Immunology, University of California, Davis, Davis, California, USA
Elizabeth A. Wohlfert
Department of Microbiology and Immunology, SUNY at Buffalo School of Medicine, Buffalo, New York, USA
Michael A. Fox
Center for Neurobiology Research, Fralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, Virginia, USA
Ira J. Blader
ORCiD Department of Microbiology and Immunology, SUNY at Buffalo School of Medicine, Buffalo, New York, USA
DOI
https://doi.org/10.1128/mBio.01331-21
Journal volume & issue
Vol. 12,
no. 3
Abstract
Read online
Inflammation in the brain caused by infections lead to seizures and other neurological symptoms. But the microbial products that induce seizures as well as the host pathways downstream of these factors are largely unknown.
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