The
<i>Toxoplasma</i>
Polymorphic Effector GRA15 Mediates Seizure Induction by Modulating Interleukin-1 Signaling in the Brain

Taylor G. Glausen; Gabriela L. Carrillo; Richard M. Jin; Jon P. Boyle; Jeroen P. J. Saeij; Elizabeth A. Wohlfert; Michael A. Fox; Ira J. Blader

doi:10.1128/mBio.01331-21

mBio (Jun 2021)

The <i>Toxoplasma</i> Polymorphic Effector GRA15 Mediates Seizure Induction by Modulating Interleukin-1 Signaling in the Brain

Taylor G. Glausen,
Gabriela L. Carrillo,
Richard M. Jin,
Jon P. Boyle,
Jeroen P. J. Saeij,
Elizabeth A. Wohlfert,
Michael A. Fox,
Ira J. Blader

Affiliations

Taylor G. Glausen: Department of Microbiology and Immunology, SUNY at Buffalo School of Medicine, Buffalo, New York, USA
Gabriela L. Carrillo: Center for Neurobiology Research, Fralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, Virginia, USA
Richard M. Jin: Department of Microbiology and Immunology, SUNY at Buffalo School of Medicine, Buffalo, New York, USA
Jon P. Boyle: Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Jeroen P. J. Saeij: ORCiD; Department of Pathology, Microbiology, and Immunology, University of California, Davis, Davis, California, USA
Elizabeth A. Wohlfert: Department of Microbiology and Immunology, SUNY at Buffalo School of Medicine, Buffalo, New York, USA
Michael A. Fox: Center for Neurobiology Research, Fralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, Virginia, USA
Ira J. Blader: ORCiD; Department of Microbiology and Immunology, SUNY at Buffalo School of Medicine, Buffalo, New York, USA

DOI: https://doi.org/10.1128/mBio.01331-21
Journal volume & issue: Vol. 12, no. 3

Abstract

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Inflammation in the brain caused by infections lead to seizures and other neurological symptoms. But the microbial products that induce seizures as well as the host pathways downstream of these factors are largely unknown.

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

About the journal